Prenatal polycyclic aromatic hydrocarbon, adiposity, peroxisome proliferator-activated receptor (PPAR Î³ methylation in offspring, grand- offspring mice.ĭirectory of Open Access Journals (Sweden)įull Text Available Greater levels of prenatal exposure to polycyclic aromatic hydrocarbon (PAH have been associated with childhood obesity in epidemiological studies. Our results indicate that early-life inflammatory insult is a plausible causative factor that induces the depressive phenotype exhibited by male adult offspring mice, most likely through a Depressive symptoms were more pronounced in male mice perinatally exposed to either intermediate or highly polluted eels than those exposed to only lowly polluted eels. Thus, compared to controls, males, but not females, whose mothers were fed eels during pregnancy and lactation exhibited a depressive-like behavior in adult age in both behavioral models of depression. Gender-specific differences were also detected in adulthood in regard to offspring resignation behavior.

However, high corticosterone levels were only found in male offspring mice that were perinatally exposed to eels, suggesting a gender-selective dysregulation of the adult hypothalamic-pituitaryadrenal (HPA) axis. The level of myeloperoxidase was found to be significantly higher in both adult males and females vs. Chronic brain inflammation was found in male and female offspring mice compared to controls, as assessed at PNDs 1, 21, and 100. Immobility behavior of offspring was assessed in adulthood (i.e., at PNDs 95-100), using the tail suspension and forced swimming tests. Plasma myeloperoxidase and corticosterone levels were evaluated at PND 100. Brain inflammatory markers including cytokines were assessed in offspring mice on the day of birth (i.e., on the postnatal day-PND 1), upon weaning (PND 21) and at adulthood (PND 100). The effects of maternal standard diet ( laboratory food) were compared to the same diet enriched with low, intermediate, or highly polluted eels. We investigated the impact of perinatal exposure to polluted eels on neonatal, postnatal, and adult brain inflammation, and on the resignation behavior of male and female adult offspring mice. Several lines of evidence indicate that early-life inflammation may predispose to mental illness, including depression, in later-life.

Soualeh, Nidhal Dridi, Imen Eppe, Gauthier NÃ©mos, Christophe Soulimani, Rachid Bouayed, Jaouad Perinatal programming of depressive-like behavior by inflammation in adult offspring mice whose mothers were fed polluted eels: Gender selective effects. The present perinatal Pb effects in the male offspring are possibly via in utero exposure and/or via mother's milk. the results of this test showed a significant and dose-dependent increase in the non-social behaviour, whereas such results showed a significant decline in the social behaviour including naso-genital and naso-nasal contact, number of fights, rear, wall rear and displacement activities of the Pb exposed young adult male offspring. After the weaning period ( 21 days ), all male offspring were isolated (one animal per cage) for 14 days, and the isolated male offspring were subjected to 'Standard Opponenttest' at the age of 36 days. Thereafter, the dams were switched to plain tap water. Treatment started from day 1 of pregnancy until day 15 postnatally. Lead ( Pb ) was given to Swiss-Webster female mice at the concentrations of 0.1 and 0.2% ( w/v ), containing 5 ppm of lead respectively, in their drinking water. International Nuclear Information System (INIS) Effect of Perinatal Lead Exposure on the Social Behaviour of Laboratory Mice Offspring at Adolescent Age

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